Romidepsin (FK228 ,Depsipeptide)

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Catalog No. A11920

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Romidepsin (FK228 ,Depsipeptide) 1mg A11920-1

Regular Price: $100.00

Special Price: $80.00

Romidepsin (FK228 ,Depsipeptide) 2mg A11920-2

Regular Price: $160.00

Special Price: $128.00

Romidepsin (FK228 ,Depsipeptide) 5mg A11920-5

Regular Price: $320.00

Special Price: $256.00

Romidepsin (FK228 ,Depsipeptide) 10mg A11920-10

Regular Price: $500.00

Special Price: $400.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.

Romidepsin (FK228 ,Depsipeptide)

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Chemical Information

Catalog Num A11920
Actions N/A
M. Wt 540.7
Formula C24H36N4O6S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 128517-07-7
Synonyms FK228, FR9N/A1228, depsipeptide, NSC 63N/A176)
SMILES code C/C=C\1/C(=O)N[[email protected]](C(=O)O[[email protected]]\2CC(=O)N[C@@H](C(=O)N[[email protected]](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C
Chemical Name Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5)-disulfide

Biological Activity

Description
Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.
Targets
HDAC1 (Cell-free assay) HDAC2 (Cell-free assay)
36 nM47 nM

Solubility

Solubility (25°C) * In vitro DMSO 10 mg/mL (18.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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