LDN193189

Catalog No.: A11205
ALK inhibitor
LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
Grouped product items
Product Name Price Stock Qty
LDN193189 2mg
$40.00
In stock
LDN193189 5mg
$70.00
In stock
LDN193189 25mg
$140.00
In stock
LDN193189 50mg
$240.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's LDN193189 has been cited by 4 publications
  • Lei Wang, .et al. , Theriogenology, 2023, Feb;197:167-176 PMID: 36525856
  • Trang Thi Huyen Dang, .et al. , Mol Cell Biochem, 2021, May;476(5):2085-2097 PMID: 33517521
  • Shizu Aikawa, .et al. , EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064
  • HIROTAKA SOMEYA, .et al. , Int J Mol Med, 2015, May; 35(5): 1169-1178 PMID: 25739055
  • Biological Activity
    Discription LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation.
    Targets
    Target Value
    Product Information
    Catalog Num A11205
    Formula C25H22N6
    Molecular Weight 406.48
    CAS Number 1062368-24-4
    SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
    Synonyms LDN-193189
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO Insoluble
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.6 mL 123.01 mL 246.01 mL
    0.5 mM 4.92 mL 24.6 mL 49.2 mL
    1 mM 2.46 mL 12.3 mL 24.6 mL
    5 mM 0.49 mL 2.46 mL 4.92 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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