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17-AAG (KOS953)

Catalog No.: A10010

HSP90 inhibitor

17-AAG (KOS953)

17-AAG (KOS953) Chemical Structure

CAS NO. 75747-14-7

17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.

Availability: In stock

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10 mg
50 mg
100 mg
200 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7

Biological Activity

17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.
HSP90 (Cell-free assay)
5 nM
In vitro (25°C) DMSO 97 mg/mL (165.61 mM)
Water Insoluble
Ethanol 5 mg/mL
In vivo 5%DMSO+corn oil 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.07 mL 85.37 mL 170.74 mL
0.5 mM 3.41 mL 17.07 mL 34.15 mL
1 mM 1.71 mL 8.54 mL 17.07 mL
5 mM 0.34 mL 1.71 mL 3.41 mL

*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10010
Actions Inhibitor
CAS No. 75747-14-7
Formula C31H43N3O8
M. Wt 585.7
Purity >98%
Synonyms Tanespimycin, NSC330507, CP 127374, KOS-953, KOS 953

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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