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- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
Biological Activity
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90.
Targets
| HSP90 (Cell-free assay) | ||||
| 5 nM |
| In vitro (25°C) | DMSO | 97 mg/mL (165.61 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL | ||
| In vivo | 5%DMSO+corn oil | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.07 mL | 85.37 mL | 170.74 mL |
| 0.5 mM | 3.41 mL | 17.07 mL | 34.15 mL |
| 1 mM | 1.71 mL | 8.54 mL | 17.07 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.41 mL |
*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10010 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 75747-14-7 |
| Formula | C31H43N3O8 |
| M. Wt | 585.7 |
| Purity | >98% |
| Synonyms | Tanespimycin, NSC330507, CP 127374, KOS-953, KOS 953 |
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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Contact information
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