Free Fatty Acid Receptor (FFAR)

TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ.

GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.