Metabotropic glutamate receptors (mGluR)

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  1. mGluR2 PAM

    JNJ-40411813 is a novel mGluR2 PAM.
  2. CNS penetrant modulator

    VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.

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