GPCR/G Protein

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  1. δ-opioid receptor modulator

    BMS-986187 is a potent and selective positive allosteric modulator (PAM) of the δ-opioid receptor and a G-protein-biased allosteric agonist.
  2. MRGPRX1 positive allosteric modulator

    ML382 is a potent and selective MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC50 of 190 nM.
  3. mGlu5 PAM

    ML-254, also known as VU0430644; is Positive Allosteric Modulators (PAMs) of mGlu5 with Competitive MPEP-Site Interaction.
  4. p75NTR modulator/proNGF antagonist

    LM11A-31 is a small-molecule p75NTR modulator and proNGF antagonist.
  5. PAM of mGluR4

    VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).

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