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- L Jin, .et al. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications, Toxicol Appl Pharmacol, 2021, Jul 13;426:115647 PMID: 34271065
- L. Jin, .et al. Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1), Toxicology and Applied Pharmacology, 2020, 398(1),
Biological Activity
A 967079 is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 48.25 mL | 241.27 mL | 482.53 mL |
| 0.5 mM | 9.65 mL | 48.25 mL | 96.51 mL |
| 1 mM | 4.83 mL | 24.13 mL | 48.25 mL |
| 5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
*The above data is based on the productmolecular weight 207.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12353 |
|---|---|
| Actions | Blocker |
| CAS No. | 1170613-55-4 |
| Formula | C12H14FNO |
| M. Wt | 207.24 |
| Purity | >98% |
| Synonyms | A-967079, A967079 |
| SMILES | CC/C(=N/O)/C(=C/C1=CC=C(C=C1)F)/C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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