Catalog No.: A12903

IDH2 R140Q inhibitor


AGI-6780 Chemical Structure

CAS NO. 1432660-47-3

AGI-6780 is a potent, selective inhibitor of mutant IDH2 with an IC50 value of 23 nM.

Availability: In stock

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5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Biological Activity

AGI-6780 is a potent, selective inhibitor of mutant IDH2 with an IC50 value of 23 nM.
IDH2 R140Q mutant
23 nM
In vitro DMSO 87 mg/mL (180.68 mM)
Water Insoluble
Ethanol 87 mg/mL (180.68 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.77 mL 103.84 mL 207.68 mL
0.5 mM 4.15 mL 20.77 mL 41.54 mL
1 mM 2.08 mL 10.38 mL 20.77 mL
5 mM 0.42 mL 2.08 mL 4.15 mL

*The above data is based on the productmolecular weight 481.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12903
Actions Inhibitor
CAS No. 1432660-47-3
Formula C21H18F3N3O3S
M. Wt 481.5
Purity >98%
Synonyms AGI6780

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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