AM251

AM251 Chemical Structure

CAS NO. 183232-66-8

AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $65.00

Special Price $58.50

25 mg

Regular Price: $125.00

Special Price $112.50

50 mg

Regular Price: $240.00

Special Price $216.00

100 mg

Regular Price: $400.00

Special Price $360.00

10mM * 1mL in DMSO

Regular Price: $106.00

Special Price $95.40

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AM251 is a potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors.
Targets
CB1
In vitro (25°C) DMSO 40 mg/mL (72.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.01 mL 90.05 mL 180.1 mL
0.5 mM 3.6 mL 18.01 mL 36.02 mL
1 mM 1.8 mL 9.01 mL 18.01 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 555.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12914
Actions Antagonist
M. Wt 555.24
Formula C22H21Cl2IN4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 183232-66-8
Synonyms AM 251, AM-251
SMILES CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I

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