AMG 837

Catalog No.: A21160

GPR40 agonist

AMG 837

AMG 837 Chemical Structure

CAS NO. 865231-46-5

AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $140.00

Special Price $112.00

10 mg

Regular Price: $242.00

Special Price $193.60

50 mg

Regular Price: $718.00

Special Price $574.40

100 mg

Regular Price: $1,435.00

Special Price $1,148.00

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Biological Activity

AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.81 mL 114.04 mL 228.08 mL
0.5 mM 4.56 mL 22.81 mL 45.62 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21160
Actions Agonist
CAS No. 865231-46-5
Formula C26H21F3O3
M. Wt 438.44
Purity >98%
SMILES OC(C[[email protected]](C#CC)C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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