AMG517

Catalog No.: A12727

TRPV1 antagonist

AMG517

AMG517 Chemical Structure

CAS NO. 659730-32-2

AMG 517 is a potent and selective TRPV1 antagonist.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
25 mg
$300.00
50 mg
$500.00
10mM * 1mL in DMSO
$136.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Jun Hai, .et al. Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice, Biosci Biotechnol Biochem, 2020, Jul 7;1-7 PMID: 32633621
  • Hai J, .et al. Differences in the effects of TRPV1 antagonists on energy metabolism in mice, Biomed Res, 2018, 39(6):279-286 PMID: 30531157

Biological Activity

AMG 517 is a potent and selective TRPV1 antagonist.
Targets
TRPV1
1 nM-2 nM
In vitro (25°C) DMSO 84 mg/mL (195.16 mM)
Water Insoluble
Ethanol Insoluble
In vivo 10% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.23 mL 116.17 mL 232.34 mL
0.5 mM 4.65 mL 23.23 mL 46.47 mL
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL

*The above data is based on the productmolecular weight 430.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12727
Actions Antagonist
CAS No. 659730-32-2
Formula C20H13F3N4O2S
M. Wt 430.4
Purity >98%
Synonyms AMG 517, AMG-517
SMILES CC(=O)NC1=NC2=C(C=CC=C2S1)OC3=NC=NC(=C3)C4=CC=C(C=C4)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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