France
You have no items in your shopping cart.
Publications citing Adooq Products
Apatinib (YN968D1) Citations (1)
- Majid Momeny,et al. Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells, Sci Rep, 2017, 7: 45954 28383032
Chemical Information
| Catalog Num | A11407 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 493.6 |
| Formula | C25H27N5O4S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 811803-05-1 |
| Synonyms | N/A |
| SMILES code | CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4 |
| Chemical Name | N-[4-(1-cyanocyclopentyl) phenyl-2-(4-picolyl)amino-3-Nicotinamide methanesulphonate |
Description |
Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. | ||||||||||||||||||
Targets |
|
||||||||||||||||||
| Solubility (25°C) * | In vitro | DMSO | 22 mg/mL (44.57 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% CMC | 6 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.26 mL | 101.3 mL | 202.59mL |
| 0.5 mM | 4.05 mL | 20.26 mL | 40.52 mL |
| 1 mM | 2.03 mL | 10.13 mL | 20.26 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.05 mL |
*The above data is based on the productmolecular weight 493.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
€42.75
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tu ...
Special Price Starting at: €42.75
Special Price Starting at:
€85.50
Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling. ...
Special Price Starting at: €85.50
Special Price Starting at:
€142.50
AST-6 is a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, inhibits tumor growth both in vitro and in vivo ...
Special Price Starting at: €142.50
Special Price Starting at:
€180.50
E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. ...
Special Price Starting at: €180.50
Special Price Starting at:
€102.60
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers. ...
Special Price Starting at: €102.60
Special Price Starting at:
€190.00
Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. ...
Special Price Starting at: €190.00
Special Price Starting at:
€59.85
SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. ...
Special Price Starting at: €59.85
Special Price Starting at:
€42.75
Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activit ...
Special Price Starting at: €42.75
Special Price Starting at:
€76.00
KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive ...
Special Price Starting at: €76.00
Special Price Starting at:
€209.00
TG 100572 is VEGFR2 and Src kinase inhibitor. ...
Special Price Starting at: €209.00
Special Price Starting at:
€76.95
AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling. ...
Special Price Starting at: €76.95
Special Price Starting at:
€42.75
Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibitor. ...
Special Price Starting at: €42.75
Special Price Starting at:
€128.25
(-)-Catechin gallate is an antioxidant constituent of green tea. At uM concentrations, inhibits VEGF-induced tyrosine phosphorylation. ...
Special Price Starting at: €128.25
Special Price Starting at:
€25.65
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. ...
Special Price Starting at: €25.65
Special Price Starting at:
€42.75
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases. ...
Special Price Starting at: €42.75
Special Price Starting at:
€51.30
R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor ty ...
Special Price Starting at: €51.30
Special Price Starting at:
€34.20
Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). ...
Special Price Starting at: €34.20
Special Price Starting at:
€142.50
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, i ...
Special Price Starting at: €142.50
Special Price Starting at:
€85.50
ZM 323881 is a potent and selective inhibitor of the kinase activity of the human vascular endothelial growth factor receptor 2 (VEGFR2/KDR). ...
Special Price Starting at: €85.50
Special Price Starting at:
€95.00
BMS-817378 is a novel prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833. ...
Special Price Starting at: €95.00
Special Price Starting at:
€57.00
ARRY-380 is an ErbB-2 inhibitor that selectively binds to and inhibits the phosphorylation of ErbB-2, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ...
Special Price Starting at: €57.00
Special Price Starting at:
€76.95
OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. ...
Special Price Starting at: €76.95
Special Price Starting at:
€85.50
SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like ty ...
Special Price Starting at: €85.50
Special Price Starting at:
€51.30
Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. ...
Special Price Starting at: €51.30
Special Price Starting at:
€34.20
Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc- ...
Special Price Starting at: €34.20
Special Price Starting at:
€55.58
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. ...
Special Price Starting at: €55.58
Special Price Starting at:
€95.00
ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) with IC50 value of 2 nM. ...
Special Price Starting at: €95.00
Special Price Starting at:
€34.20
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM. ...
Special Price Starting at: €34.20
Special Price Starting at:
€85.50
Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine ki ...
Special Price Starting at: €85.50
Special Price Starting at:
€190.00
CP-547632 is a novel, potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ...
Special Price Starting at: €190.00
Keywords:buy Apatinib (YN968D1) | Apatinib (YN968D1) Supplier | purchase Apatinib (YN968D1) | Apatinib (YN968D1) cost | Apatinib (YN968D1) manufacturer | order Apatinib (YN968D1) | Apatinib (YN968D1) distributor | buy 811803-05-1| 811803-05-1 Supplier | purchase 811803-05-1 | 811803-05-1 cost | 811803-05-1 manufacturer | order 811803-05-1 | 811803-05-1 distributor
We Using Safe Payments:
