Apatinib (YN968D1)

Catalog No.: A11407

VEGFR inhibitor

Apatinib (YN968D1) Chemical Structure

CAS NO. 811803-05-1

Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $100.00

Special Price $80.00

10 mg

Regular Price: $150.00

Special Price $120.00

50 mg

Regular Price: $350.00

Special Price $280.00

100 mg

Regular Price: $450.00

Special Price $360.00

10mM * 1mL in DMSO
$110.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue.
Targets
Target Value
VEGFR2IC50: 1nM
RETIC50: 13nM
c-KitIC50: 429nM
c-SrcIC50: 530nM
PDGFRαIC50: >1μM
EGFRIC50: >10μM
HER2IC50: >10μM
FGFR1IC50: >10μM
In vitro (25°C) DMSO 22 mg/mL (44.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.26 mL 101.3 mL 202.59 mL
0.5 mM 4.05 mL 20.26 mL 40.52 mL
1 mM 2.03 mL 10.13 mL 20.26 mL
5 mM 0.41 mL 2.03 mL 4.05 mL

*The above data is based on the productmolecular weight 493.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11407
Actions Inhibitor
M. Wt 493.6
Formula C25H27N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 811803-05-1
SMILES CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4

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