Apatinib (YN968D1)

Catalog No.: A11407

VEGFR inhibitor

Apatinib (YN968D1)

Apatinib (YN968D1) Chemical Structure

CAS NO. 811803-05-1

Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$150.00
50 mg
$350.00
100 mg
$450.00
10mM * 1mL in DMSO
$110.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Majid Momeny, .et al. Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells, Sci Rep, 2017, 7: 45954 PMID: 28383032

Biological Activity

Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue.
Targets
Target Value
VEGFR2IC50: 1nM
RETIC50: 13nM
c-KitIC50: 429nM
c-SrcIC50: 530nM
PDGFRαIC50: >1μM
EGFRIC50: >10μM
HER2IC50: >10μM
FGFR1IC50: >10μM
In vitro DMSO 77 mg/mL (193.72 mM)
Water Insoluble
Ethanol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.26 mL 101.3 mL 202.59 mL
0.5 mM 4.05 mL 20.26 mL 40.52 mL
1 mM 2.03 mL 10.13 mL 20.26 mL
5 mM 0.41 mL 2.03 mL 4.05 mL

*The above data is based on the productmolecular weight 493.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11407
Actions Inhibitor
CAS No. 811803-05-1
Formula C25H27N5O4S
M. Wt 493.6
Purity >98%
SMILES CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy Apatinib (YN968D1) | Apatinib (YN968D1) Supplier | purchase | cost | manufacturer | order | distributor | buy 811803-05-1| 811803-05-1 Supplier | purchase 811803-05-1 | 811803-05-1 cost | 811803-05-1 manufacturer | order 811803-05-1 | 811803-05-1 distributor
Rewards