AZ-960

Name: AZ-960
Brand: Adooq Bioscience
SKU: A10104
Rating: 100 (268 reviews)

Catalog No.: A10104

JAK2inhibitor

AZ-960 Chemical Structure

CAS NO. 905586-69-8

AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell.

Availability: In stock

Package	Price	Qty
5 mg	$200.00
10 mg	$320.00
25 mg	$550.00
50 mg	$920.00
10mM * 1mL in DMSO	$201.00
Custom Size	Get quote

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Biological Activity

AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell.

Targets

JAK2	JAK2
0.45 nM(Ki)	<3 nM

Solubility *

In vitro	DMSO	70 mg/mL (197.54 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (8.46 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.22 mL	141.08 mL	282.17 mL
0.5 mM	5.64 mL	28.22 mL	56.43 mL
1 mM	2.82 mL	14.11 mL	28.22 mL
5 mM	0.56 mL	2.82 mL	5.64 mL

*The above data is based on the productmolecular weight 354.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10104
Actions	Inhibitor
CAS No.	905586-69-8
Formula	C18H16F2N6
M. Wt	354.4
Purity	>98%
Synonyms	AZ960
SMILES	CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[[email protected]@H](C)C3=CC=C(C=C3)F)C#N)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.