Bedaquiline (TMC-207)

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
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Product Name Price Stock Qty
Bedaquiline (TMC-207) 5mg
Special Price $44.00 Regular Price $55.00
In stock
Bedaquiline (TMC-207) 10mg
Special Price $64.00 Regular Price $80.00
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Bedaquiline (TMC-207) 50mg
Special Price $136.00 Regular Price $170.00
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Adooq Products cited in reputable paper
Adooq's Bedaquiline (TMC-207) has been cited by 15 publications
  • Thanh Quang Nguyen, .et al. , Microbiol Spectr, 2023, Jun 15;11(3):e0063123 PMID: 37158736
  • Rubeshan Perumal, .et al. , Infect Drug Resist, 2023, May 9;16:2849-2859 PMID: 37193296
  • Christian C Otum, .et al. , Sci Rep, 2023, Jun 6;13(1):9212 PMID: 37280265
  • Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819
  • Jinsheng Cui, .et al. , Mar Drugs, 2022, Jun 16;20(6):400 PMID: 35736203
  • Bettina Schulthess, .et al. , Antimicrob Agents Chemother, 2022, May 17;66(5) PMID: 35420492
  • Puyskens A, .et al. , Cell Host Microbe, 2019, Dec 23. pii: S1931-3128(19)30634-1 PMID: 31901518
  • Belosludtsev KN, .et al. , Biochim Biophys Acta Biomembr, 2019, Jan;1861(1):288-297 PMID: 29920239
  • Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Belosludtsev KN, .et al. , Chem Biol Interact, 2018, Nov 26;299:8-14 PMID: 30496736
  • Wu X, .et al. , Biochem Biophys Res Commun, 2018, Jan 1;495(1):267-272 PMID: 29107691
  • Jichan Jang, .et al. , Antimicrob Agents Chemother, 2017, Jul; 61(7): e02637-16 PMID: 28416541
  • Marco Fiorillo, .et al. , Aging (Albany NY), 2016, Aug; 8(8): 1593-1606 PMID: 27344270
  • Alvaro A. Ordonez, .et al. , Antimicrob Agents Chemother, 2015, Jan; 59(1): 642-649 PMID: 25403669
  • Ke Liu, .et al. , Drug Metab Dispos, 2014, May; 42(5): 863-866 PMID: 24513655
  • Biological Activity
    Discription TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
    Product Information
    Catalog Num A12327
    Formula C32H31BrN2O2
    Molecular Weight 555.5
    CAS Number 843663-66-1
    SMILES CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 11 mg/mL (19.8 mM)
    Water Insoluble
    Ethanol 3 mg/mL (5.4 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18 mL 90.01 mL 180.02 mL
    0.5 mM 3.6 mL 18 mL 36 mL
    1 mM 1.8 mL 9 mL 18 mL
    5 mM 0.36 mL 1.8 mL 3.6 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

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      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

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      C2

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