Bedaquiline (TMC-207)

Catalog No.: A12327

Bedaquiline (TMC-207)

Bedaquiline (TMC-207) Chemical Structure

CAS NO. 843663-66-1

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.

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5 mg
$55.00
10 mg
$80.00
50 mg
$170.00
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  • Puyskens A, .et al. Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes, Cell Host Microbe, 2019, Dec 23. pii: S1931-3128(19)30634-1 PMID: 31901518
  • Belosludtsev KN, .et al. Effect of bedaquiline on the functions of rat liver mitochondria, Biochim Biophys Acta Biomembr, 2019, Jan;1861(1):288-297 PMID: 29920239
  • Wu X, .et al. Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism, Biochem Biophys Res Commun, 2018, Jan 1;495(1):267-272 PMID: 29107691
  • Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Belosludtsev KN, .et al. Interaction of the anti-tuberculous drug bedaquiline with artificial membranes and rat erythrocytes, Chem Biol Interact, 2018, Nov 26;299:8-14 PMID: 30496736
  • Jichan Jang, .et al. Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2017, Jul; 61(7): e02637-16 PMID: 28416541
  • Marco Fiorillo, .et al. Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs), Aging (Albany NY), 2016, Aug; 8(8): 1593-1606 PMID: 27344270
  • Alvaro A. Ordonez, .et al. Radioiodinated DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice, Antimicrob Agents Chemother, 2015, Jan; 59(1): 642-649. PMID: 25403669
  • Ke Liu, .et al. Bedaquiline Metabolism: Enzymes and Novel Metabolites, Drug Metab Dispos., 2014, May; 42(5): 863-866 PMID: 24513655

Biological Activity

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18 mL 90.01 mL 180.02 mL
0.5 mM 3.6 mL 18 mL 36 mL
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 555.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12327
M. Wt 555.5
Formula C32H31BrN2O2
Solubility DMSO
Purity >97%
Storage at -20°C 3 years Powder
CAS No. 843663-66-1
SMILES CN(C)CC[[email protected]@](C1=CC=CC2=CC=CC=C21)([[email protected]](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O

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