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Bedaquiline (TMC-207)

Catalog No.: A12327

Bedaquiline (TMC-207)

Bedaquiline (TMC-207) Chemical Structure

CAS NO. 843663-66-1

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.

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  • Jinsheng Cui, .et al. Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp, Mar Drugs, 2022, Jun 16;20(6):400 PMID: 35736203
  • Bettina Schulthess, .et al. In Vitro Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus, Antimicrob Agents Chemother, 2022, May 17;66(5) PMID: 35420492
  • Puyskens A, .et al. Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes, Cell Host Microbe, 2019, Dec 23. pii: S1931-3128(19)30634-1 PMID: 31901518
  • Belosludtsev KN, .et al. Effect of bedaquiline on the functions of rat liver mitochondria, Biochim Biophys Acta Biomembr, 2019, Jan;1861(1):288-297 PMID: 29920239
  • Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Belosludtsev KN, .et al. Interaction of the anti-tuberculous drug bedaquiline with artificial membranes and rat erythrocytes, Chem Biol Interact, 2018, Nov 26;299:8-14 PMID: 30496736
  • Wu X, .et al. Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism, Biochem Biophys Res Commun, 2018, Jan 1;495(1):267-272 PMID: 29107691
  • Jichan Jang, .et al. Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2017, Jul; 61(7): e02637-16 PMID: 28416541
  • Marco Fiorillo, .et al. Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs), Aging (Albany NY), 2016, Aug; 8(8): 1593-1606 PMID: 27344270
  • Alvaro A. Ordonez, .et al. Radioiodinated DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice, Antimicrob Agents Chemother, 2015, Jan; 59(1): 642-649 PMID: 25403669
  • Ke Liu, .et al. Bedaquiline Metabolism: Enzymes and Novel Metabolites, Drug Metab Dispos, 2014, May; 42(5): 863-866 PMID: 24513655

Biological Activity

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.
In vitro DMSO 11 mg/mL (19.8 mM)
Water Insoluble
Ethanol 3 mg/mL (5.4 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18 mL 90.01 mL 180.02 mL
0.5 mM 3.6 mL 18 mL 36 mL
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 555.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12327
CAS No. 843663-66-1
Formula C32H31BrN2O2
M. Wt 555.5
Purity >97%
SMILES CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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