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Bedaquiline (TMC-207)


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Catalog No. A12327

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Bedaquiline (TMC-207) 5mg A12327-5

Regular Price: $150.00

Special Price: $135.00

Bedaquiline (TMC-207) 10mg A12327-10

Regular Price: $250.00

Special Price: $225.00

Bedaquiline (TMC-207) 25mg A12327-25

Regular Price: $520.00

Special Price: $468.00

Bedaquiline (TMC-207) 50mg A12327-50

Regular Price: $880.00

Special Price: $792.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.

Bedaquiline (TMC-207)

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Publications citing Adooq Products
Bedaquiline (TMC-207) Citations (8)
  • Belosludtsev KN, .et al. Effect of bedaquiline on the functions of rat liver mitochondria, Biochim Biophys Acta Biomembr, 2019, Jan;1861(1):288-297 PMID: 29920239
  • Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Belosludtsev KN, .et al. Interaction of the anti-tuberculous drug bedaquiline with artificial membranes and rat erythrocytes, Chem Biol Interact, 2018, Nov 26;299:8-14 PMID: 30496736
  • Wu X, .et al. Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism, Biochem Biophys Res Commun, 2018, Jan 1;495(1):267-272 PMID: 29107691
  • Jichan Jang, .et al. Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2017, Jul; 61(7): e02637-16 PMID: 28416541
  • Marco Fiorillo, .et al. Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs), Aging (Albany NY), 2016, Aug; 8(8): 1593-1606 PMID: 27344270
  • Alvaro A. Ordonez, .et al. Radioiodinated DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice, Antimicrob Agents Chemother, 2015, Jan; 59(1): 642-649. PMID: 25403669
  • Ke Liu, .et al. Bedaquiline Metabolism: Enzymes and Novel Metabolites, Drug Metab Dispos., 2014, May; 42(5): 863-866 PMID: 24513655

Chemical Information

Catalog Num A12327
Actions N/A
M. Wt 555.5
Formula C32H31BrN2O2
Solubility DMSO
Purity >97%
Storage at -20°C 3 years Powder
CAS No. 843663-66-1
Synonyms Sirturo, TMC2N/A7, R2N/A791N/A
SMILES CN(C)CC[[email protected]@](C1=CC=CC2=CC=CC=C21)([[email protected]](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O

Biological Activity

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18 mL 90.01 mL 180.02mL
0.5 mM 3.6 mL 18 mL 36 mL
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 555.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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