Metabolism

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  1. Notch inhibitor

    LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM.
  2. SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice.

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