Endogenous Metabolite

Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca2+ influx, and DHT-like effects.

N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.

m-Tyramine is an endogenous trace amine neuromodulor. m-Tyramine has effects on the adrenergic and dopaminergic receptor.

N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.

8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions.

Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses.

Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines.

Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease.

Docosapentaenoic acid (22n-3) is a component of phospholipids found in all animal cell membranes.

3-Hydroxydodecanoic acid is a medium-chain fatty acid associated with fatty acid metabolic disorders.

2-Hydroxyadipic acid is an organic acid, formed by the reduction of 2-ketoadipic acid.

Paullinic acid is a long-chain fatty acid that has been detected in multiple biofluids, such as blood and urine.

Argininic acid is an α-amino acid that is used in the biosynthesis of proteins.

Mevalonic acid, a precursor in the mevalonate pathway, is essential for cell growth and proliferation.

Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.

Stigmastanol is a phytosterol found in a variety of plant sources.

Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.

Imidazoleacetic acid is an endogenous ligand that stimulates imidazole receptors.

3-Hydroxyglutaric acid is a glutaric acid derivative.

Tiglyl carnitine is found to be associated with celiac disease and mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.

2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

Ursolic acid, a naturally occurring triterpenoid, induces the apoptosis of human cancer cells through multiple signaling pathways.

γ-Glu-Gly, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids.

Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.