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multi-targeted tyrosine kinase inhibitor

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Catalog No. A14210

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Cerdulatinib 10mg A14210-10

Regular Price: €85.50

Special Price: €76.95

Cerdulatinib 25mg A14210-25

Regular Price: €190.00

Special Price: €171.00

Cerdulatinib 50mg A14210-50

Regular Price: €332.50

Special Price: €299.25

Cerdulatinib 10mM * 1mL in DMSO A14210-10mM-D

Regular Price: €96.90

Special Price: €87.21

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.


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Chemical Information

Catalog Num A14210
Actions Inhibitor
M. Wt 482
Formula C20H28ClN7O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1369761-01-2
Synonyms PRT062070, PRT2070, PRT-2070

Biological Activity

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.
Target Value
TYK2IC50: 0.5nM
MST1IC50: 4nM
ARK5IC50: 4nM
MLK1IC50: 5nM
FmsIC50: 5nM
JAK2IC50: 6nM
JAK3IC50: 8nM
TBK1IC50: 10nM
MARK1IC50: 10nM
JAK1IC50: 12nM
PAR1B-aIC50: 13nM
TSSKIC50: 14nM
MST2IC50: 15nM
GCKIC50: 18nM
JNK3IC50: 18nM
RSK2IC50: 20nM
RSK4IC50: 28nM
SykIC50: 32nM
Chk1IC50: 42nM
FLT4IC50: 51nM
FLT3IC50: 90nM
RETIC50: 105nM
ITKIC50: 194nM


Solubility (25°C)* In vitro DMSO 43 mg/mL heating (89.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.75 mL 103.73 mL 207.47mL
0.5 mM 4.15 mL 20.75 mL 41.49 mL
1 mM 2.07 mL 10.37 mL 20.75 mL
5 mM 0.41 mL 2.07 mL 4.15 mL

*The above data is based on the productmolecular weight 482. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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