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Catalog No.: A11085

GSK-3 inhibitor


CHIR-98014 Chemical Structure

CAS NO. 252935-94-7

CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.

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Biological Activity

CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.
Target Value
GSK-3βIC50: 0.58nM
GSK-3αIC50: 0.65nM
p70S6KIC50: >1μM
c-SrcIC50: >1μM
bFGFRIC50: >1μM
KDRIC50: >2μM
IGF-1RIC50: >2μM
Insulin ReceptorIC50: >2μM
Cdc2IC50: 3.7μM
Akt1IC50: >5μM
Tie-2IC50: >5μM
FLT1IC50: >5μM
CK1εIC50: >5μM
ERK2IC50: >10μM
PKCαIC50: >10μM
p90RSK2IC50: >10μM
Chk1IC50: >10μM
DNA-PKIC50: >10μM
PI3KIC50: >10μM
In vitro (25°C) DMSO Warmed: 7 mg/mL (14.39 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+corn oil 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.56 mL 102.82 mL 205.63 mL
0.5 mM 4.11 mL 20.56 mL 41.13 mL
1 mM 2.06 mL 10.28 mL 20.56 mL
5 mM 0.41 mL 2.06 mL 4.11 mL

*The above data is based on the productmolecular weight 486.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11085
Actions Inhibitor
CAS No. 252935-94-7
Formula C20H17Cl2N9O2
M. Wt 486.3
Purity >98%
Synonyms CHIR98014
SMILES C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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