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CX-4945 (Silmitasertib)

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CK2 inhibitor

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Catalog No. A11060

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CX-4945 (Silmitasertib) 2mg A11060-2

Regular Price: $40.00

Special Price: $36.00

CX-4945 (Silmitasertib) 5mg A11060-5

Regular Price: $80.00

Special Price: $72.00

CX-4945 (Silmitasertib) 10mg A11060-10

Regular Price: $130.00

Special Price: $117.00

CX-4945 (Silmitasertib) 50mg A11060-50

Regular Price: $350.00

Special Price: $315.00

CX-4945 (Silmitasertib) 10mM * 1mL in DMSO A11060-10mM-D

Regular Price: $85.00

Special Price: $76.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.

CX-4945 (Silmitasertib)

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Publications citing Adooq Products
CX-4945 (Silmitasertib) Citations (7)
  • Fukumoto Y,et al. Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17, Biochem Biophys Res Commun, 2018, Oct 2;504(2):380-386 29902452
  • ST Ribeiro,et al. Casein kinase 2 controls the survival of normal thymic and leukemic 污汛 T cells via promotion of AKT signaling, Leukemia, 2017, Jul; 31(7): 1603-1610 27899804
  • Valentina Gandin,et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly, Nat Commun, 2016, 7: 11127 27040916
  • Ampofo E,et al. Protein Kinase CK2 Regulates Leukocyte-Endothelial Cell Interactions during Ischemia and Reperfusion in Striated Skin Muscle, Eur Surg Res, 2016, 57(1-2):111-24 27287005
  • Emmanuel Ampofo,et al. Role of protein kinase CK2 in the dynamic interaction of platelets, leukocytes and endothelial cells during thrombus formation., Thromb Res., 2015, Nov;136(5):996-1006 26381437
  • Emmanuel Ampofo,et al. Inhibition of protein kinase CK2 suppresses tumor necrosis factor (TNF)-汐-induced leukocyte-endothelial cell interaction., Biochim Biophys Acta., 2015, Oct;1852(10 Pt A):2123-36 26189586
  • A. Margarida Gomes,et al. Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels, Haematologica, 2014, 99(6): 1062-1068 24561792

Chemical Information

Catalog Num A11060
Actions Inhibitor
M. Wt 349.8
Formula C19H12ClN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1009820-21-6
Synonyms Silmitasertib, CX 4945, CX4945
SMILES code C1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O
Chemical Name 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid

Biological Activity

Description
CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
Targets
CK2 (Cell-free assay)
1 nM

Solubility

Solubility (25°C)* In vitro DMSO 16 mg/mL (45.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.59 mL 142.94 mL 285.88mL
0.5 mM 5.72 mL 28.59 mL 57.18 mL
1 mM 2.86 mL 14.29 mL 28.59 mL
5 mM 0.57 mL 2.86 mL 5.72 mL

*The above data is based on the productmolecular weight 349.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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