CX-4945 (Silmitasertib)

Catalog No.: A11060

CK2 inhibitor

CX-4945 (Silmitasertib)

CX-4945 (Silmitasertib) Chemical Structure

CAS NO. 1009820-21-6

CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.

Availability: In stock

Package Price Qty
2 mg

Regular Price: $40.00

Special Price $32.00

5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $130.00

Special Price $104.00

50 mg

Regular Price: $350.00

Special Price $280.00

10mM * 1mL in DMSO
$85.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
Targets
CK2 (Cell-free assay)
1 nM
In vitro DMSO 16 mg/mL (45.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.59 mL 142.94 mL 285.88 mL
0.5 mM 5.72 mL 28.59 mL 57.18 mL
1 mM 2.86 mL 14.29 mL 28.59 mL
5 mM 0.57 mL 2.86 mL 5.72 mL

*The above data is based on the productmolecular weight 349.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11060
Actions Inhibitor
M. Wt 349.8
Formula C19H12ClN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1009820-21-6
Synonyms Silmitasertib, CX 4945, CX4945
SMILES C1=CC(=CC(=C1)Cl)NC2=C3C=CN=CC3=C4C=CC(=CC4=N2)C(=O)O

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