IWR-1-endo
Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Discription | IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. | ||
---|---|---|---|
Targets |
|
Catalog Num | A12737 |
---|---|
Formula | C25H19N3O3 |
Molecular Weight | 409.44 |
CAS Number | 1127442-82-3 |
SMILES | C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 19 mg/mL (46.4 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.42 mL | 122.12 mL | 244.24 mL |
0.5 mM | 4.88 mL | 24.42 mL | 48.85 mL |
1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2