AZ5104
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Discription | AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1. | ||
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Catalog Num | A15516 |
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Formula | C27H31N7O2 |
Molecular Weight | 485.58 |
CAS Number | 1421373-98-9 |
SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC |
Synonyms | AZ-5104, AZ 5104 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 90 mg/mL (185.34 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 21 mg/mL (43.24 mM) | ||
In vivo | 1% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 20.59 mL | 102.97 mL | 205.94 mL |
0.5 mM | 4.12 mL | 20.59 mL | 41.19 mL |
1 mM | 2.06 mL | 10.3 mL | 20.59 mL |
5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2