GNF 5837
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. | ||
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Targets |
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Catalog Num | A13730 |
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Formula | C28H21F4N5O2 |
Molecular Weight | 535.49 |
CAS Number | 1033769-28-6 |
SMILES | CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4 |
Synonyms | GNF-5837, GNF5837 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 92 mg/mL (171.8 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 8 mg/mL (14.93 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 18.67 mL | 93.37 mL | 186.74 mL |
0.5 mM | 3.73 mL | 18.67 mL | 37.35 mL |
1 mM | 1.87 mL | 9.34 mL | 18.67 mL |
5 mM | 0.37 mL | 1.87 mL | 3.73 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2