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FABP4 Inhibitor is a cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively).
| In vitro | DMSO | 89 mg/mL (187.54 mM) | |
| Water | Insoluble | ||
| Ethanol | 17 mg/mL (35.82 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.07 mL | 105.36 mL | 210.73 mL |
| 0.5 mM | 4.21 mL | 21.07 mL | 42.15 mL |
| 1 mM | 2.11 mL | 10.54 mL | 21.07 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
*The above data is based on the productmolecular weight 474.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13404 |
|---|---|
| CAS No. | 300657-03-8 |
| Formula | C31H26N2O3 |
| M. Wt | 474.55 |
| Solubility | DMSO |
| Purity | >98% |
| SMILES | CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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