GDC-0032 (Taselisib)

Catalog No.: A12831

PI3K inhibitor

GDC-0032 (Taselisib)

GDC-0032 (Taselisib) Chemical Structure

CAS NO. 1282512-48-4

GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$110.00
25 mg
$200.00
50 mg
$290.00
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Biological Activity

GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha.
Targets
Target Value
PI3Kδki: 0.12nM
PI3Kαki: 0.29nM
PI3Kγki: 0.97nM
PI3Kβki: 9.1nM
C2βIC50: 292nM
hVps34IC50: 374nM
mTORki: 1.2μM
DNA-PKIC50: >4.8μM
C2αIC50: >10μM
In vitro DMSO Warmed: 62 mg/mL (134.62 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.71 mL 108.57 mL 217.14 mL
0.5 mM 4.34 mL 21.71 mL 43.43 mL
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL

*The above data is based on the productmolecular weight 460.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12831
Actions Inhibitor
CAS No. 1282512-48-4
Formula C24H28N8O2
M. Wt 460.53
Purity >98%
Synonyms GDC 0032, GDC0032
SMILES CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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