Total item
Cart Subtotal
$0.00 Biological Activity
GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha.
Targets
| Target | Value |
|---|---|
| PI3Kδ | ki: 0.12nM |
| PI3Kα | ki: 0.29nM |
| PI3Kγ | ki: 0.97nM |
| PI3Kβ | ki: 9.1nM |
| C2β | IC50: 292nM |
| hVps34 | IC50: 374nM |
| mTOR | ki: 1.2μM |
| DNA-PK | IC50: >4.8μM |
| C2α | IC50: >10μM |
| In vitro | DMSO | Warmed: 62 mg/mL (134.62 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.71 mL | 108.57 mL | 217.14 mL |
| 0.5 mM | 4.34 mL | 21.71 mL | 43.43 mL |
| 1 mM | 2.17 mL | 10.86 mL | 21.71 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
*The above data is based on the productmolecular weight 460.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12831 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1282512-48-4 |
| Formula | C24H28N8O2 |
| M. Wt | 460.53 |
| Purity | >98% |
| Synonyms | GDC 0032, GDC0032 |
| SMILES | CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy GDC-0032 (Taselisib) | GDC-0032 (Taselisib) Supplier | purchase | cost | manufacturer | order | distributor | buy 1282512-48-4| 1282512-48-4 Supplier | purchase 1282512-48-4 | 1282512-48-4 cost | 1282512-48-4 manufacturer | order 1282512-48-4 | 1282512-48-4 distributor
Featured PI3K inhibitors
-
BAY 80-6946 (Copanlisib)
BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. -
BEZ235 (NVP-BEZ235, Dactolisib)
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. -
BKM120 (NVP-BKM120, Buparlisib)
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. -
BYL719 (Alpelisib)
BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. -
CAL-101 (GS-1101, Idelalisib)
CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells. -
CUDC-907 (Fimepinostat)
CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses. -
CZC24832
CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). -
GDC-0941 (Pictilisib)
GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. -
GSK1059615
GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM). -
GSK2636771
GSK2636771 is a potent, orally bioavailable, PI3K beta-selective inhibitor. -
LY294002
LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor. -
LY3023414
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). -
NU-7441 (KU-57788)
NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. -
PI-3065
PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM -
PIK-75 hydrochloride
PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively. -
PIK-93
PIK 93 selectively inhibits the type III PI 4-kinase enzyme, and small interfering RNA-mediated down-regulation of the individual PI 4-kinase enzymes. -
TGX-221
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β. -
XL147 analogue
XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity. -
YM201636
YM201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM). -
ZSTK474
ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms.
Adooq Quality Guarantee
We promise all products perform as described.