GDC0994 (Ravoxertinib)

Catalog No.: A13420

ERK1/2 inhibitor

GDC0994 (Ravoxertinib)

GDC0994 (Ravoxertinib) Chemical Structure

CAS NO. 1453848-26-4

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$100.00
25 mg
$190.00
10mM * 1mL in DMSO
$85.00
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Biological Activity

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
Targets
ERK2 ERK1
0.3 nM1.1 nM
In vitro (25°C) DMSO 83 mg/mL (188.7 mM)
Water Insoluble
Ethanol 83 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.68 mL 113.41 mL 226.82 mL
0.5 mM 4.54 mL 22.68 mL 45.36 mL
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13420
Actions Inhibitor
CAS No. 1453848-26-4
Formula C21H18ClFN6O2
M. Wt 440.87
Purity >98%
Synonyms GDC-0994
SMILES CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[[email protected]](CO)C4=CC(=C(C=C4)Cl)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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