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ERK1/2 inhibitor

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Catalog No. A13420

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GDC0994 5mg A13420-5

Regular Price: $80.00

Special Price: $72.00

GDC0994 10mg A13420-10

Regular Price: $100.00

Special Price: $90.00

GDC0994 25mg A13420-25

Regular Price: $190.00

Special Price: $171.00

GDC0994 10mM * 1mL in DMSO A13420-10mM-D

Regular Price: $85.00

Special Price: $76.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.


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Chemical Information

Catalog Num A13420
Actions Inhibitor
M. Wt 440.87
Formula C21H18ClFN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1453848-26-4
Synonyms GDC-0994
SMILES CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[[email protected]](CO)C4=CC(=C(C=C4)Cl)F

Biological Activity

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
0.3 nM1.1 nM


Solubility (25°C)* In vitro DMSO 88 mg/mL (200.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 88 mg/mL (200.06 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.68 mL 113.41 mL 226.82mL
0.5 mM 4.54 mL 22.68 mL 45.36 mL
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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