GSK256066

Catalog No.: A11073

PDE Inhibitor

GSK256066 Chemical Structure

CAS NO. 801312-28-7

GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17).

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$220.00
50 mg
$600.00
100 mg
$980.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17).
Targets
PDE4B
3.2 pM
In vitro (25°C) DMSO 5 mg/mL (9.64 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.28 mL 96.41 mL 192.83 mL
0.5 mM 3.86 mL 19.28 mL 38.57 mL
1 mM 1.93 mL 9.64 mL 19.28 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 518.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11073
Actions Inhibitor
M. Wt 518.6
Formula C27H26N4O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 801312-28-7
Synonyms GSK-256066
SMILES CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C=N2)C(=O)N)NC4=CC(=CC=C4)OC

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