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GYKI-52466 dihydrochloride

AMPA and Kainate antagonist

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Catalog No. A10444

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GYKI-52466 dihydrochloride 10mg A10444-10
GYKI-52466 dihydrochloride 25mg A10444-25
GYKI-52466 dihydrochloride 50mg A10444-50
GYKI-52466 dihydrochloride 100mg A10444-100

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GYKI-52466 dihydrochloride is selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively).

GYKI-52466 dihydrochloride

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Chemical Information

Catalog Num A10444
Actions Antagonist
M. Wt 366.24
Formula C17H15N3O2.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 102771-26-6
Synonyms GYKI52466, GYKI 52466
SMILES code CC1=NN=C(C2=CC3=C(C=C2C1)OCO3)C4=CC=C(C=C4)N
Chemical Name 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2?,3]benzodiazepin-5-yl)-benzenamine dihydrochloride

Biological Activity

GYKI-52466 dihydrochloride is selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively).

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.3 mL 136.52 mL 273.04mL
0.5 mM 5.46 mL 27.3 mL 54.61 mL
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

*The above data is based on the productmolecular weight 366.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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