LY2811376

Catalog No.: A11776

BACE1 inhibitor

LY2811376 Chemical Structure

CAS NO. 1194044-20-6

LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$500.00
100 mg
$850.00
10mM * 1mL in DMSO
$117.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
Targets
BACE1
239 nM-249 nM~300 nM(EC50)
In vitro (25°C) DMSO 16 mg/mL (49.94 mM)
Water <1 mg/mL (<1 mM)
Ethanol 64 mg/mL (199.77 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.21 mL 156.05 mL 312.11 mL
0.5 mM 6.24 mL 31.21 mL 62.42 mL
1 mM 3.12 mL 15.61 mL 31.21 mL
5 mM 0.62 mL 3.12 mL 6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11776
Actions Inhibitor
M. Wt 320.4
Formula C15H14F2N4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1194044-20-6
Synonyms LY 2811376, LY-2811376
SMILES C[[email protected]]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F

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