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- Marlene Dallmayer, .et al. Targeting the CALCB/RAMP1-axis inhibits growth of Ewing sarcoma, bioRxiv, 2018, 2018
|Storage||at -20°C 3 years Powder|
|SMILES code||C1CCC2(C1)C(=O)N([[email protected]@H](CN2)C3=CC(=CC(=C3)F)F)CC(=O)NC4=CC5=C(C[[email protected]@]6(C5)C7=C(NC6=O)N=CC=C7)C=C4.Cl|
|Chemical Name||(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-6,9-diazaspiro[4.5]decane-9-acetamide hydrochloride|
|MK 3207 hydrochloride is a potent CGRP receptor antagonist with IC50 of 0.12 nM.|
|Solubility (25°C) *||In vitro||DMSO||119 mg/mL (200.31 mM)|
|Water||5 mg/mL (8.41 mM)|
|Ethanol||119 mg/mL (200.31 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||16.83 mL||84.16 mL||168.32mL|
|0.5 mM||3.37 mL||16.83 mL||33.66 mL|
|1 mM||1.68 mL||8.42 mL||16.83 mL|
|5 mM||0.34 mL||1.68 mL||3.37 mL|
*The above data is based on the productmolecular weight 594.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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