Motesanib (AMG706) Chemical Structure

CAS NO. 453562-69-1

Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$50.00
25 mg
$90.00
50 mg
$160.00
10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).
In vitro (25°C) DMSO 100 mg/mL heating (175.61 mM)
Water 19 mg/mL heating (33.36 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.78 mL 133.89 mL 267.77 mL
0.5 mM 5.36 mL 26.78 mL 53.55 mL
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL

*The above data is based on the productmolecular weight 373.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11496
Actions Inhibitor
M. Wt 373.45
Formula C22H23N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 453562-69-1
Synonyms AMG 706, AMG-706
SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C

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