Total item
Cart Subtotal
$0.00 Biological Activity
Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).
| In vitro (25°C) | DMSO | 100 mg/mL heating (175.61 mM) | |
| Water | 19 mg/mL heating (33.36 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | Saline | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.78 mL | 133.89 mL | 267.77 mL |
| 0.5 mM | 5.36 mL | 26.78 mL | 53.55 mL |
| 1 mM | 2.68 mL | 13.39 mL | 26.78 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
*The above data is based on the productmolecular weight 373.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11496 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 373.45 |
| Formula | C22H23N5O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 453562-69-1 |
| Synonyms | AMG 706, AMG-706 |
| SMILES | CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an ora…
Taxifolin
Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibi…
E-7050 (Golvatinib)
E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (v…
Tivozanib (AV-951)
Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors.
E7080 (Lenvatinib)
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
TG 100572
TG 100572 is VEGFR2 and Src kinase inhibitor.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
ZM 306416 hydrochloride
ZM 306416 is a VEGF receptor tyrosine kinase inhibitor that inhibits KDR (IC50 = 100 nM) and Flt (IC50 = 2 uM) tyrosine kinases.
Keywords:buy Motesanib (AMG706) | Motesanib (AMG706) Supplier | purchase Motesanib (AMG706) | Motesanib (AMG706) cost | Motesanib (AMG706) manufacturer | order Motesanib (AMG706) | Motesanib (AMG706) distributor | buy 453562-69-1| 453562-69-1 Supplier | purchase 453562-69-1 | 453562-69-1 cost | 453562-69-1 manufacturer | order 453562-69-1 | 453562-69-1 distributor
Adooq Quality Guarantee
We promise all products perform as described.