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Biological Activity
MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor.
Targets
| c-Kit (D816H) | PDGFRα (V561D) | FLT3 (D835Y) | ||
| 10 nM | 40 nM | 81 nM |
| In vitro (25°C) | DMSO | 30 mg/mL (67.03 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+95% Corn oil | 4.2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.35 mL | 111.73 mL | 223.46 mL |
| 0.5 mM | 4.47 mL | 22.35 mL | 44.69 mL |
| 1 mM | 2.23 mL | 11.17 mL | 22.35 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.47 mL |
*The above data is based on the productmolecular weight 447.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10610 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 850879-09-3 |
| Formula | C23H21N5O3S |
| M. Wt | 447.5 |
| Purity | >98% |
| Synonyms | Amuvatinib |
| SMILES | C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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