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Nalfurafine hydrochloride

Catalog No.: A12579

opioid κ-selective agonist

Nalfurafine hydrochloride

Nalfurafine hydrochloride Chemical Structure

CAS NO. 152658-17-8

Nalfurafine hydrochloride is a kappa-opioid receptor agonist

Availability: In stock

Package Price Qty
2 mg

Regular Price: $180.00

Special Price $144.00

5 mg

Regular Price: $350.00

Special Price $280.00

10 mg

Regular Price: $640.00

Special Price $512.00

25 mg

Regular Price: $1,180.00

Special Price $944.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Alexander R French, .et al. Sex- and β-arrestin-dependent effects of kappa opioid receptor-mediated ethanol consumption, Pharmacol Biochem Behav, 2022, May;216:173377 PMID: 35364122
  • Wen-Wen Zhang, .et al. Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice, JCI Insight, 2022, Feb 8;7(3):e153191 PMID: 34914639
  • A Dunn, .et al. Modulation of Cocaine-Related Behaviors by Low Doses of the Potent KOR Agonist Nalfurafine in Male C57BL6 Mice, Psychopharmacology (Berl), 2020, May 20 PMID: 32435819
  • Dunn AD, .et al. Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses, ACS Chem Neurosci, 2019, Aug 21;10(8):3590-3600 PMID: 31313902
  • Anika Mann, .et al. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists, Sci Signal, 2019, Mar 26;12(574). pii: eaau8072 PMID: 30914485
  • Snyder LM, .et al. Kappa Opioid Receptor Distribution and Function in Primary Afferents, Neuron, 2018, Sep 19;99(6):1274-1288.e6 PMID: 30236284

Biological Activity

Nalfurafine hydrochloride is a kappa-opioid receptor agonist
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.49 mL 97.46 mL 194.92 mL
0.5 mM 3.9 mL 19.49 mL 38.98 mL
1 mM 1.95 mL 9.75 mL 19.49 mL
5 mM 0.39 mL 1.95 mL 3.9 mL

*The above data is based on the productmolecular weight 513.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12579
Actions Agonist
CAS No. 152658-17-8
Formula C28H33ClN2O5
M. Wt 513.03
Purity >98%
Synonyms AC-820, TRK-820, Remitch
SMILES CN([[email protected]@H]1CC[[email protected]]2([[email protected]]3CC4=C5[[email protected]]2([[email protected]]1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)/C=C/C7=COC=C7.Cl

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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