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$0.00 - A Dunn, .et al. Modulation of Cocaine-Related Behaviors by Low Doses of the Potent KOR Agonist Nalfurafine in Male C57BL6 Mice, Psychopharmacology (Berl), 2020, May 20 PMID: 32435819
- Anika Mann, .et al. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists, Sci Signal, 2019, Mar 26;12(574). pii: eaau8072 PMID: 30914485
- Dunn AD, .et al. Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses, ACS Chem Neurosci, 2019, Aug 21;10(8):3590-3600 PMID: 31313902
- Snyder LM, .et al. Kappa Opioid Receptor Distribution and Function in Primary Afferents, Neuron, 2018, Sep 19;99(6):1274-1288.e6 PMID: 30236284
Biological Activity
Nalfurafine hydrochloride is a kappa-opioid receptor agonist
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.49 mL | 97.46 mL | 194.92 mL |
| 0.5 mM | 3.9 mL | 19.49 mL | 38.98 mL |
| 1 mM | 1.95 mL | 9.75 mL | 19.49 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.9 mL |
*The above data is based on the productmolecular weight 513.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12579 |
|---|---|
| Actions | Agonist |
| CAS No. | 152658-17-8 |
| Formula | C28H33ClN2O5 |
| M. Wt | 513.03 |
| Purity | >98% |
| Synonyms | AC-820, TRK-820, Remitch |
| SMILES | CN([[email protected]@H]1CC[[email protected]]2([[email protected]]3CC4=C5[[email protected]]2([[email protected]]1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)/C=C/C7=COC=C7.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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