Neuronal Signaling

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  1. M1 modulator

    TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
  2. partial M1 agonist and M2/M3 antagonist

    Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.

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