PF-3845

Catalog No.: A11183

FAAH Inhibitor

PF-3845

PF-3845 Chemical Structure

CAS NO. 1196109-52-0

PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism.

Availability: In stock

Package Price Qty
10 mg
$70.00
50 mg
$300.00
100 mg
$500.00
10mM * 1mL in DMSO
$91.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism.

Targets
FAAH
230 nM(Ki)
In vitro (25°C) DMSO 87 mg/mL (190.6 mM)
Water Insoluble
Ethanol 87 mg/mL (190.6 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.91 mL 109.54 mL 219.08 mL
0.5 mM 4.38 mL 21.91 mL 43.82 mL
1 mM 2.19 mL 10.95 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11183
Actions Inhibitor
CAS No. 1196109-52-0
Formula C24H23F3N4O2
M. Wt 456.46
Purity >98%
Synonyms PF3845
SMILES C1CN(CCC1CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=CN=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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