Target & Activity
| Target | Activity | Value |
|---|---|---|
| FAAH | Ki | 230 nM |
Fig. 1 · Structure
Documents & Downloads
PF-3845
Cat. No.
A11183
CAS
1196109-52-0
FAAH Inhibitor
PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1196109-52-0 |
| Applications | FAAH Inhibitor |
| Formula | C24H23F3N4O2 |
| Molecular Weight | 456.46 |
| SMILES | C1CN(CCC1CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=CN=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 87 mg/mL (190.6 mM) |
| Water | Insoluble |
| Ethanol | 87 mg/mL (190.6 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 14 mg/mL
- Vehicle
- 30% propylene glycol, 5% Tween 80, 65% D5W
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.