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PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
Targets
| Target | Value |
|---|---|
| SRMS | IC50: 18nM |
| ACK1 | IC50: 19nM |
| B-Raf(V600E) | IC50: 31nM |
| C-Raf | IC50: 48nM |
| MAP4K5(KHS1) | IC50: 51nM |
| FGR | IC50: 63nM |
| B-Raf | IC50: 100nM |
| LCK | IC50: 183nM |
| BRK | IC50: 213nM |
| NEK11 | IC50: 317nM |
| BLK | IC50: 547nM |
| LynB | IC50: 599nM |
| YES1 | IC50: 604nM |
| WNK3 | IC50: 877nM |
| MNK2 | IC50: 1.717μM |
| FRK(PTK5) | IC50: 1.884μM |
| CSK | IC50: 2.339μM |
| Src | IC50: 2.389μM |
| In vitro (25°C) | DMSO | 98 mg/mL (200.03 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.41 mL | 102.06 mL | 204.12 mL |
| 0.5 mM | 4.08 mL | 20.41 mL | 40.82 mL |
| 1 mM | 2.04 mL | 10.21 mL | 20.41 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
*The above data is based on the productmolecular weight 489.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10739 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 489.9 |
| Formula | C23H18ClF2N3O3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 918504-65-1 |
| Synonyms | RG7204,RO5185426,Zelboraf, PLX-4032 |
| SMILES | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F |
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