PLX4032 (Vemurafenib)

PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
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Product Name Price Stock Qty
PLX4032 10mg
$40.00
In stock
PLX4032 50mg
$90.00
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PLX4032 100mg
$120.00
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PLX4032 200mg
$200.00
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PLX4032 10mM * 1mL in DMSO
$50.00
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Adooq Products cited in reputable paper
Adooq's PLX4032 (Vemurafenib) has been cited by 12 publications
  • Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
  • Lee YJ, .et al. , Research Square, 2022, April 27th
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Guixin Zhu, .et al. , Nat Cell Biol, 2021, Sep;23(9):978-991 PMID: 34497368
  • Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840
  • Kudo K, .et al. , FASEB J, 2018, Dec 3:fj201800664RR PMID: 30508500
  • Min Ho Choe, .et al. , Cell Death Dis, 2018, Jun; 9(6): 640 PMID: 29844307
  • Jan Dorrie, .et al. , Int J Mol Sci, 2018, Jan; 19(1): 289 PMID: 29346301
  • Aishwarya Kundu, .et al. , Mol Carcinog, 2017, Jan; 56(1): 49-61 PMID: 26878440
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Toshinori Sueda, .et al. , Sci Rep, 2016, 6: 18949 PMID: 26750638
  • Yanling Li, .et al. , Onco Targets Ther, 2015, 8: 1043-1051 PMID: 25999739
  • Biological Activity
    Discription PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
    Targets
    Target Value
    Product Information
    Catalog Num A10739
    Formula C23H18ClF2N3O3S
    Molecular Weight 489.9
    CAS Number 918504-65-1
    SMILES CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
    Synonyms RG7204,RO5185426,Zelboraf
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 83 mg/mL (169.41 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O (suspension) 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.41 mL 102.06 mL 204.12 mL
    0.5 mM 4.08 mL 20.41 mL 40.82 mL
    1 mM 2.04 mL 10.21 mL 20.41 mL
    5 mM 0.41 mL 2.04 mL 4.08 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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