United States
You have no items in your shopping cart.
Publications citing Adooq Products
PLX4032 (Vemurafenib) Citations (7)
- Kudo K, .et al. Cell surface CD63 increased by up-regulated polylactosamine modification sensitizes human melanoma cells to the BRAF inhibitor PLX4032, FASEB J, 2018, Dec 3:fj201800664RR PMID: 30508500
- Min Ho Choe, .et al. miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP, Cell Death Dis, 2018, Jun; 9(6): 640 PMID: 29844307
- Jan Dörrie, .et al. BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy, Int J Mol Sci, 2018, Jan; 19(1): 289 PMID: 29346301
- Aishwarya Kundu, .et al. Inhibition of Oncogenic BRAF Activity by Indole-3-Carbinol Disrupts Microphthalmia-Associated Transcription Factor Expression and Arrests Melanoma Cell Proliferation, Mol Carcinog, 2017, Jan; 56(1): 49–61. PMID: 26878440
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
- Toshinori Sueda, .et al. BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells, Sci Rep, 2016, 6: 18949 PMID: 26750638
- Yanling Li, .et al. Tyrphostin AG1296, a platelet-derived growth factor receptor inhibitor, induces apoptosis, and reduces viability and migration of PLX4032-resistant melanoma cells, Onco Targets Ther., 2015, 8: 1043–1051 PMID: 25999739
Chemical Information
| Catalog Num | A10739 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 489.9 |
| Formula | C23H18ClF2N3O3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 918504-65-1 |
| Synonyms | RG7204,RO5185426,Zelboraf, PLX-4032 |
| SMILES code | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F |
| Chemical Name | N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide |
Description |
PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM. | ||||||||||||||||||||||||||||||||||||||
Targets |
|
||||||||||||||||||||||||||||||||||||||
| Solubility (25°C) * | In vitro | DMSO | 98 mg/mL (200.03 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.41 mL | 102.06 mL | 204.12mL |
| 0.5 mM | 4.08 mL | 20.41 mL | 40.82 mL |
| 1 mM | 2.04 mL | 10.21 mL | 20.41 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
*The above data is based on the productmolecular weight 489.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$200.00
Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. ...
Special Price Starting at: $200.00
Special Price Starting at:
$63.00
Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5. ...
Special Price Starting at: $63.00
Special Price Starting at:
$240.00
Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. ...
Special Price Starting at: $240.00
Special Price Starting at:
$36.00
ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. ...
Special Price Starting at: $36.00
Special Price Starting at:
$190.00
CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM, respectively. ...
Special Price Starting at: $190.00
Special Price Starting at:
$350.00
Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. ...
Special Price Starting at: $350.00
Special Price Starting at:
$70.00
AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF. ...
Special Price Starting at: $70.00
Special Price Starting at:
$100.00
BRAF inhibitor is a potent BRAF inhibitor.
...
Special Price Starting at: $100.00
Special Price Starting at:
$150.00
MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials. ...
Special Price Starting at: $150.00
Special Price Starting at:
$150.00
ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively). ...
Special Price Starting at: $150.00
Special Price Starting at:
$108.00
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers. ...
Special Price Starting at: $108.00
Special Price Starting at:
$150.00
Kobe2602 is an analog of Kobe0065. Exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 149 ± 55 μM. ...
Special Price Starting at: $150.00
Special Price Starting at:
$45.00
Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial. ...
Special Price Starting at: $45.00
Special Price Starting at:
$72.00
KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity ...
Special Price Starting at: $72.00
Special Price Starting at:
$65.00
TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio. ...
Special Price Starting at: $65.00
Special Price Starting at:
$45.00
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tu ...
Special Price Starting at: $45.00
Special Price Starting at:
$72.00
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. ...
Special Price Starting at: $72.00
Special Price Starting at:
$80.00
Dabigatran ethyl ester, which is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity. ...
Special Price Starting at: $80.00
Special Price Starting at:
$90.00
LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity. ...
Special Price Starting at: $90.00
Special Price Starting at:
$90.00
SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively. ...
Special Price Starting at: $90.00
Special Price Starting at:
$108.00
B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively ...
Special Price Starting at: $108.00
Special Price Starting at:
$350.00
PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively. ...
Special Price Starting at: $350.00
Special Price Starting at:
$320.00
HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738. ...
Special Price Starting at: $320.00
Special Price Starting at:
$81.00
GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM). ...
Special Price Starting at: $81.00
Special Price Starting at:
$140.00
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. ...
Special Price Starting at: $140.00
Special Price Starting at:
$54.00
GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor ...
Special Price Starting at: $54.00
Special Price Starting at:
$150.00
PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-ex ...
Special Price Starting at: $150.00
Special Price Starting at:
$60.00
L-779450 is a raf kinase inhibitor, a potential treatment for neurotraumatic diseases. ...
Special Price Starting at: $60.00
Special Price Starting at:
$70.00
PLX-4720 is a B-raf inhibitor with IC50 of 160 nM. ...
Special Price Starting at: $70.00
Keywords:buy PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) Supplier | purchase PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) cost | PLX4032 (Vemurafenib) manufacturer | order PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) distributor | buy 918504-65-1| 918504-65-1 Supplier | purchase 918504-65-1 | 918504-65-1 cost | 918504-65-1 manufacturer | order 918504-65-1 | 918504-65-1 distributor
We Using Safe Payments:
