Posaconazole

Catalog No.: A10744

CYP3A4 inhibitor

Posaconazole

Posaconazole Chemical Structure

CAS NO. 171228-49-2

Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
25 mg
$180.00
50 mg
$300.00
10mM * 1mL in DMSO
$143.00
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Biological Activity

Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.
Targets
lanosterol 14α-demethylase
In vitro (25°C) DMSO 90 mg/mL (128.42 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.27 mL 71.35 mL 142.69 mL
0.5 mM 2.85 mL 14.27 mL 28.54 mL
1 mM 1.43 mL 7.13 mL 14.27 mL
5 mM 0.29 mL 1.43 mL 2.85 mL

*The above data is based on the productmolecular weight 700.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10744
Actions Inhibitor
CAS No. 171228-49-2
Formula C37H42F2N8O4
M. Wt 700.8
Purity >98%
Synonyms Noxafil
SMILES CC[[email protected]@H]([[email protected]](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[[email protected]]5C[[email protected]](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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