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Biological Activity
Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.
Targets
| lanosterol 14α-demethylase | ||||
| In vitro (25°C) | DMSO | 90 mg/mL (128.42 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.27 mL | 71.35 mL | 142.69 mL |
| 0.5 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 1 mM | 1.43 mL | 7.13 mL | 14.27 mL |
| 5 mM | 0.29 mL | 1.43 mL | 2.85 mL |
*The above data is based on the productmolecular weight 700.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10744 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 171228-49-2 |
| Formula | C37H42F2N8O4 |
| M. Wt | 700.8 |
| Purity | >98% |
| Synonyms | Noxafil |
| SMILES | CC[[email protected]@H]([[email protected]](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[[email protected]]5C[[email protected]](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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