Pregnane X Receptors
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Meclizine 2HCl
Catalog No. A11700 Meclizine is a human pregnane X receptor (hPXR) agonist. It possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Its antiemetic and antivertigo effects are not fully understood, but its central anticholinergic properties are partially responsible. Learn More -
Pregnenolone
Catalog No. A11909 Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively. Learn More -
Rifampin
Catalog No. A10791 RNA polymerase inhibitorAntibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR). Learn More -
SR-12813
Catalog No. A16125