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Biological Activity
PRX-08066, a Novel 5-Hydroxytryptamine Receptor 2B Antagonist, reduced monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.
| In vitro | DMSO | 92 mg/mL (177.61 mM) | |
| Water | 92 mg/mL (177.61 mM) | ||
| Ethanol | 86 mg/mL (166.03 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.88 mL | 124.41 mL | 248.82 mL |
| 0.5 mM | 4.98 mL | 24.88 mL | 49.76 mL |
| 1 mM | 2.49 mL | 12.44 mL | 24.88 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.98 mL |
*The above data is based on the productmolecular weight 401.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13267 |
|---|---|
| Actions | Antagonist |
| CAS No. | 866206-54-4 |
| Formula | C19H17ClFN5S |
| M. Wt | 401.89 |
| Purity | >98% |
| Synonyms | PRX08066, PRX 08066 |
| SMILES | C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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