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$0.00 Biological Activity
Reboxetine is an antidepressant compound that selectively inhibits norepinephrine uptake (IC50s = 8.2 and 1,070 nM for norepinephrine and serotonin transporters, respectively). It displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or dopamine receptors (Kis = 1.1, 129, 1,400, 3,900, and >10,000 nM, respectively).
Targets
| norepinephrine reuptake | ||||
| 8.2 nM(Ki) |
| In vitro | DMSO | 81 mg/mL (197.8 mM) | |
| Water | 81 mg/mL (197.8 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.42 mL | 122.1 mL | 244.2 mL |
| 0.5 mM | 4.88 mL | 24.42 mL | 48.84 mL |
| 1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
*The above data is based on the productmolecular weight 409.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11919 |
|---|---|
| CAS No. | 98769-84-7 |
| Formula | C19H23NO3.CH4SO3 |
| M. Wt | 409.5 |
| Purity | >98% |
| SMILES | CCOC1=CC=CC=C1O[[email protected]@H]([[email protected]]2CNCCO2)C3=CC=CC=C3.CS(=O)(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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