SB 239063

Catalog No.: A11562

p38 MAPK inhibitor

SB 239063

SB 239063 Chemical Structure

CAS NO. 193551-21-2

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

Availability: In stock

Package Price Qty
2 mg
$60.00
5 mg
$90.00
10 mg
$160.00
25 mg
$300.00
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Biological Activity

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
Targets
p38α p38β
44 nM44 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.14 mL 135.72 mL 271.44 mL
0.5 mM 5.43 mL 27.14 mL 54.29 mL
1 mM 2.71 mL 13.57 mL 27.14 mL
5 mM 0.54 mL 2.71 mL 5.43 mL

*The above data is based on the productmolecular weight 368.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11562
Actions Inhibitor
M. Wt 368.4
Formula C20H21FN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 193551-21-2
Synonyms SB239063, SB-239063
SMILES COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F

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