SB 239063

Catalog No.: A11562

p38 MAPK inhibitor

SB 239063

SB 239063 Chemical Structure

CAS NO. 193551-21-2

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

Availability: In stock

Package Price Qty
2 mg
$60.00
5 mg
$90.00
10 mg
$160.00
25 mg
$300.00
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Biological Activity

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
Targets
p38α p38β
44 nM44 nM
In vitro (25°C) DMSO 59 mg/mL (160.15 mM)
Water Insoluble
Ethanol Warmed: 7 mg/mL (19 mM)
In vivo 5% DMSO+30% PEG 300+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.14 mL 135.72 mL 271.44 mL
0.5 mM 5.43 mL 27.14 mL 54.29 mL
1 mM 2.71 mL 13.57 mL 27.14 mL
5 mM 0.54 mL 2.71 mL 5.43 mL

*The above data is based on the productmolecular weight 368.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11562
Actions Inhibitor
CAS No. 193551-21-2
Formula C20H21FN4O2
M. Wt 368.4
Solubility DMSO
Purity >98%
Synonyms SB239063, SB-239063
SMILES COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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