SB 239063
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo. | ||
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Catalog Num | A11562 |
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Formula | C20H21FN4O2 |
Molecular Weight | 368.4 |
CAS Number | 193551-21-2 |
SMILES | COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F |
Synonyms | SB239063, SB-239063 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 59 mg/mL (160.15 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 7 mg/mL (19 mM) | ||
In vivo | 5% DMSO+30% PEG 300+ddH2O | 3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 27.14 mL | 135.72 mL | 271.44 mL |
0.5 mM | 5.43 mL | 27.14 mL | 54.29 mL |
1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2