Tesevatinib

Catalog No.: A21875

multi-target tyrosine kinase inhibitor

Tesevatinib

Tesevatinib Chemical Structure

CAS NO. 781613-23-8

Tesevatinib (XL-647; EXEL-7647; KD-019) is an orally available, multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, Flt4 and EphB4 kinase with IC50s of 0.3, 16, 1.5, 8.7, and 1.4 nM.

Availability: In stock

Package Price Qty
5 mg
$324.00
10 mg
$558.00
50 mg
$1,656.00
100 mg
$3,312.00
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Biological Activity

Tesevatinib (XL-647; EXEL-7647; KD-019) is an orally available, multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, Flt4 and EphB4 kinase with IC50s of 0.3, 16, 1.5, 8.7, and 1.4 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.35 mL 101.75 mL 203.5 mL
0.5 mM 4.07 mL 20.35 mL 40.7 mL
1 mM 2.04 mL 10.18 mL 20.35 mL
5 mM 0.41 mL 2.04 mL 4.07 mL

*The above data is based on the productmolecular weight 491.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21875
Actions Inhibitor
M. Wt 491.39
Formula C24H25Cl2FN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 781613-23-8
Synonyms XL-647, XL647, XL 647; EXEL-7647, EXEL7647, EXEL 7647; KD-019, KD019, KD 019
SMILES [H][[email protected]@]12[[email protected]@](C[[email protected]@H](COC3=CC4=C(C(NC5=C(F)C(Cl)=C(Cl)C=C5)=NC=N4)C=C3OC)C2)([H])CN(C)C1

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