TH5487

Catalog No.: A18537

OGG1 inhibitor

TH5487

TH5487 Chemical Structure

CAS NO. 2304947-71-3

TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
50 mg
$650.00
100 mg
$1,150.00
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Biological Activity

TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.48 mL 92.39 mL 184.78 mL
0.5 mM 3.7 mL 18.48 mL 36.96 mL
1 mM 1.85 mL 9.24 mL 18.48 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 541.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18537
Actions Inhibitor
M. Wt 541.18
Formula C19H18BrIN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2304947-71-3
Synonyms TH 5487; TH5487; TH-5487
SMILES O=C(N1CCC(N(C2=CC=CC(Br)=C2N3)C3=O)CC1)NC4=CC=C(I)C=C4

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