GPCR/G Protein

JNJ-40411813 is a novel mGluR2 PAM.

GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120).

GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 (GPR120).

E1R is a novel positive allosteric modulator of sigma-1 receptors.

NEO 376 is a selective modulator of 5-HT1 receptor, GABA receptor and dopamine receptor, with anti-psychotic actively.

VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.

AZD8797 is an allosteric non-competitive and orally active modulator of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively.

BMS-986188 is a novel Potent and Selective Positive Allosteric Modulator of the delta-Opioid Receptor.

BMS-986187 is a potent and selective positive allosteric modulator (PAM) of the δ-opioid receptor and a G-protein-biased allosteric agonist.