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Catalog No.
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Application
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Product Citation
orexin 1 receptor antagonist
GSK1059865 is a potent orexin 1 receptor antagonist.
Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists.
ACT-335827 is a selective orexin receptor 1 antagonist.
Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.
1 publications
Ryan J Keenan, .et al. , Br J Pharmacol , 2022, Jul;179(13):3403-3417 PMID: 35112344
IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.
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