Prostanoid Receptors

NS-304 is a selective prostacyclin IP1 receptor agonist (Ki values are 260 and 2100 nM and for human and rat IP receptors, and >10 μM for EP1-4, DP, FP, and TP receptors).

MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

Taprenepag isopropyl is a highly selective EP2 receptor agonist.

Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6??0.1 and 6.2??1.2 nM, respectively.