TNF-α

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13?nM.