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- Cladribine is a synthetic anti-cancer agent that mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA.
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Adenosine deaminase inhibitor
Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM).- Lifang Han, .et al. , Cell Rep, 2022, May 31;39(9) PMID: 35649375
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Adenosine deaminase inhibitor
EHNA hydrochloride is a specific inhibitor of adenosine deaminase, prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.