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Metabolism
LXR

LXR

Catalog No.

Product Name

Application

Product Information

Product Citation

A12865

Cerpegin

Cerpegin is a naturally occurring pyridinone alkaloid isolated from Roxb, a tradional indian medicine used as an anti-inflammatory, analgesic, antiulcer and tranquilizer.

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A15100

GW3965

Liver X Receptor Agonist

GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively.

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- B Dong ,etc. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. Journal of lipid research, 2013, 54(5), 1241-1254.
- N Pencheva ,etc. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation. Cell, 2014, 156(5), 986-1001.
A17017

GSK-2033

LXR antagonist

GSK-2033 is a potent cell-active LXR antagonist (pIC50 = 7.5). It enhances T-cell proliferation and blocks T 0901317-antiproliferative activity on T-cells and is cell permeable.

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A19270

XL041

LXRβ-selective agonist

XL041 (BMS-852927) is an LXRβ-selective agonist.

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