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Evodiamine is a chemical extracted from the Tetradium family of plants. It acts primarily as a thermogenic and stimulant.
PF-4840154 is a non-electrophilic reference agonist of the TrpA1 channel. The TRPA1 channel is considered an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of pain behaviors in some pre-clinical development models.
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).
WS 3 is TRPM8 receptors agonist (EC50 = 3.7 μM) and cooling agent.
JT010 is a potent agonist of TRPA1 with an EC50 of 0.65 nM.
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
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