β-lactamase

Durlobactam, also known as ETX2514, is a beta-lactamase inhibitor drug candidate.

VNRX-5133 is a cyclic boronate β-lactamase inhibitor.

Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases.

Taniborbactam is a potent inhibitor of β-lactamase, with IC50s of <100 nM for SHV-5, KPC-2, VIM-2, and AmpC β-lactamase, and 0.1 to 1 μM for OXA-1 β-lactamase, used in the research of bacterial infections.

BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) .

Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL.